Kundi Harun, Gök Murat, Topçuoglu Canan, Ornek Ender
Cardiology Department, Numune Education and Research Hospital, Ankara, Turkey.
Kardiol Pol. 2017;75(10):990-996. doi: 10.5603/KP.a2017.0119. Epub 2017 Jun 14.
Serglycin plays an important role in the inflammatory status, but the relationship between coronary artery ectasia (CAE) and serglycin is still unknown.
In this study, we aimed to investigate the association of serglycin level with isolated CAE.
Fifty-two patients with isolated CAE and 35 individuals with normal coronary angiography were included into the study. The Markis classification and number of ectatic coronary arteries were recorded. Plasma serglycin levels were measured.
Multivariate logistic regression analysis revealed that serglycin and high-sensitivity C-reactive protein were indepen-dently associated with the presence of CAE. In receiver operating characteristics curve analysis the cut of serglycin level for the prediction of isolated CAE was 13.5, with a sensitivity of 88.5% and a specificity of 84.8%. However, there was no association between serglycin levels and Markis classification.
Serglycin levels are significantly and independently higher in patients with CAE.
丝甘素在炎症状态中起重要作用，但冠状动脉扩张（CAE）与丝甘素之间的关系仍不清楚。
在本研究中，我们旨在探讨丝甘素水平与孤立性CAE的关联。
本研究纳入了52例孤立性CAE患者和35例冠状动脉造影正常的个体。记录Markis分类和扩张冠状动脉的数量。测量血浆丝甘素水平。
多因素logistic回归分析显示，丝甘素和高敏C反应蛋白与CAE的存在独立相关。在受试者工作特征曲线分析中，预测孤立性CAE的丝甘素水平切点为13.5，灵敏度为88.5%，特异度为84.8%。然而，丝甘素水平与Markis分类之间没有关联。
CAE患者的丝甘素水平显著且独立升高。
