CRUK Beatson Institute, Bearsden, Glasgow, UK.
Institute of Cancer Sciences, University of Glasgow, Glasgow, UK.
J Pathol. 2018 May;245(1):3-5. doi: 10.1002/path.5029. Epub 2018 Mar 1.
Recent next-generation sequencing studies demonstrate that multiple pathways are often deregulated in advanced and metastatic prostate cancer (PC). In a recent issue of The Journal of Pathology, an elegant study by Jefferies et al used in vivo modelling to demonstrate how activation of the PI3K, WNT, and MAPK pathway converges on mTORC1 signalling to drive aggressive disease. The study also highlights that approaches to target advanced PC require intelligent combination of agents to target single/multiple signalling pathways in combination with androgen receptor (AR) blockade. Copyright © 2018 Pathological Society of Great Britain and Ireland. Published by John Wiley & Sons, Ltd.
最近的下一代测序研究表明，晚期和转移性前列腺癌（PC）中经常有多个途径失调。在最近一期的《病理学杂志》上，Jefferies 等人发表了一项优雅的研究，该研究使用体内模型证明了 PI3K、WNT 和 MAPK 途径的激活如何汇聚到 mTORC1 信号传导上，从而导致侵袭性疾病。该研究还强调，针对晚期 PC 的方法需要智能地将药物组合在一起，以靶向单一/多种信号通路，并与雄激素受体（AR）阻断相结合。版权所有 © 2018 英国和爱尔兰病理学会。由 John Wiley & Sons，Ltd. 出版。
