辅助性T细胞对IgG上的独特型起反应，而不对IgM上的独特型起反应。
Helper T cells reacting to idiotype on IgG but not IgM.
作者信息
Saito T, Rajewsky K
出版信息
J Exp Med. 1985 Oct 1;162(4):1399-404. doi: 10.1084/jem.162.4.1399.
Abstract
Immunization with an IgG1 but not an IgM monoclonal anti-NP (4-hydroxy-3-nitrophenyl acetyl) antibody induced idiotype-recognizing T helper cells, although these two antibodies carry the same variable regions. The T cells appear to react to an idiotype on the IgG1 but not the IgM antibody. They selectively enhance the expression of that idiotype in the IgG1 fraction of an in vitro anti-NP response.
摘要
用IgG1而非IgM单克隆抗-NP（4-羟基-3-硝基苯基乙酰）抗体进行免疫接种可诱导识别独特型的辅助性T细胞，尽管这两种抗体携带相同的可变区。这些T细胞似乎对IgG1抗体上的独特型有反应，而对IgM抗体则无反应。它们在体外抗-NP反应的IgG1组分中选择性地增强该独特型的表达。
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Idiotype-anti-idiotype network. II. Activation of silent clones by treatment at birth with idiotypes is associated with the expansion of idiotype-specific helper T cells.独特型-抗独特型网络。II. 出生时用独特型进行治疗激活沉默克隆与独特型特异性辅助性T细胞的扩增相关。
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Eur J Immunol. 1985 May;15(5):512-20. doi: 10.1002/eji.1830150517.
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