Department of Bio-science and Engineering, Shibaura Institute of Technology, Saitama, Saitama, Japan.
Faculty of Nursing and Rehabilitation, Konan Women's University, Kobe, Hyogo, Japan.
Nutr Rev. 2018 Mar 1;76(3):174-186. doi: 10.1093/nutrit/nux070.
Foods rich in flavan 3-ols are known to prevent cardiovascular diseases by reducing metabolic syndrome risks, such as hypertension, hyperglycemia, and dyslipidemia. However, the mechanisms involved in this reduction are unclear, particularly because of the poor bioavailability of flavan 3-ols. Recent metabolome analyses of feces produced after repeated ingestion of foods rich in flavan 3-ols may provide insight into the chronic physiological changes associated with the intake of flavan 3-ols. Substantial postprandial changes have been reported after flavan 3-ol ingestion, including hemodynamic and metabolic changes as well as autonomic and central nervous alterations. Taken together, the evidence suggests that flavan 3-ols have both postprandial and chronic effects, which could involve different or common mechanisms. In general, the accumulation of acute functional changes induces chronic physiological alteration. Therefore, this review highlights the postprandial action of flavan 3-ols in order to address the yet unknown mechanism(s) for their physiological function.
富含黄烷醇的食物被认为可以通过降低代谢综合征的风险（如高血压、高血糖和血脂异常）来预防心血管疾病。然而，其涉及的机制尚不清楚，特别是因为黄烷醇的生物利用度较差。最近对重复摄入富含黄烷醇的食物后产生的粪便进行的代谢组学分析，可能有助于深入了解与黄烷醇摄入相关的慢性生理变化。在摄入黄烷醇后，已经报道了大量的餐后变化，包括血流动力学和代谢变化以及自主和中枢神经系统改变。总之，证据表明黄烷醇具有餐后和慢性作用，这可能涉及不同或共同的机制。一般来说，急性功能变化的积累会导致慢性生理变化。因此，本综述强调了黄烷醇的餐后作用，以探讨其生理功能的未知机制。
