ANBAS Corporation, Toyosaki Kita-ku, Osaka, Japan.
Physiol Res. 2020 Apr 30;69(2):253-260. doi: 10.33549/physiolres.934277. Epub 2020 Mar 23.
Beneficial effects of sesame lignans, especially antioxidative effects, have been widely reported; however, its potential effects on autonomic nerves have not yet been investigated. Therefore, the current study aimed to investigate the effect of sesame lignans on the autonomic nervous system. The sympathetic nerve activity in rat skeletal muscle was measured using electrophysiological approaches, with blood flow determined using the laser Doppler method. Sesame lignans were administered intragastrically at 2 and 20 mg/kg, and after 60 min, the sympathetic nerve activity was observed to increase by 45.2% and 66.1%, respectively. A significant increase in blood flow (39.6%) was also observed for the 20-mg/kg dose when measured at 55 min after administration. These sympathomimetic effects were completely prevented by subdiaphragmatic vagotomy, and the increase in blood flow was eliminated in the presence of the beta2-adrenergic receptor inhibitor butoxamine. Thus, it is proposed that sesame lignans can increase the blood flow of skeletal muscle, possibly by exciting sympathetic nerve activity through the afferent vagal nerve.
芝麻木脂素具有有益的作用，特别是抗氧化作用，这已经得到了广泛的报道；然而，其对自主神经系统的潜在影响尚未得到研究。因此，本研究旨在探讨芝麻木脂素对自主神经系统的影响。通过电生理方法测量大鼠骨骼肌中的交感神经活动，并使用激光多普勒法测定血流量。芝麻木脂素以 2 和 20mg/kg 的剂量经胃内给药，给药 60 分钟后，交感神经活动分别增加了 45.2%和 66.1%。给药后 55 分钟测量时，20mg/kg 剂量也观察到血流量显著增加（39.6%）。膈下迷走神经切断术完全预防了这些拟交感作用，而存在β2-肾上腺素能受体抑制剂丁氧胺时，血流增加被消除。因此，提出芝麻木脂素可以通过刺激传入迷走神经来增加骨骼肌的血流量，可能是通过兴奋交感神经活动。
