Institut für Organische Chemie und Chemische Biologie, Goethe-Universität Frankfurt, Max-von-Laue-Str. 7, 60438, Frankfurt/Main, Germany.
Chemistry. 2018 Aug 14;24(46):11852-11863. doi: 10.1002/chem.201705470. Epub 2018 Mar 13.
Molecules containing a sulfonyl functionality, such as sulfones, sulfonyl chlorides or sulfonamides play an important role in organic chemistry and have found widespread application, especially in the construction of biologically active compounds. Recently, methods for the synthesis of the sulfonyl moiety utilizing sulfur dioxide as a key building block have received considerable attention. In this context, radical-based transformations with sulfur dioxide have emerged as a new and attractive approach for the construction of the sulfonyl functional group. This short review highlights recent advances in the use of sulfur dioxide in radical reactions and covers the historical background, which forms the basis for these current progresses. Limitations of the existing methods and potential further developments will be discussed.
含有磺酰基官能团的分子，如砜、磺酰氯或磺胺类药物，在有机化学中起着重要的作用，并且已经得到了广泛的应用，特别是在生物活性化合物的构建中。最近，利用二氧化硫作为关键构建块合成磺酰基部分的方法受到了相当多的关注。在这种情况下，基于二氧化硫的自由基转化已成为构建磺酰基官能团的一种新的、有吸引力的方法。这篇简短的综述强调了二氧化硫在自由基反应中的最新应用进展，并涵盖了这些当前进展的历史背景。本文还讨论了现有方法的局限性和潜在的进一步发展方向。
