Department of Chemistry, University College of Science, Osmania University, Hyderabad 500 007, India.
Org Biomol Chem. 2021 Apr 14;19(14):3087-3118. doi: 10.1039/d1ob00111f. Epub 2021 Mar 24.
This review mainly focuses on recent developments in the preparation of β-keto sulfones and their extensive synthetic applications. New prospects for the synthesis of β-keto thiosulfones have also been highlighted. Over the last decade, there has been exponential growth in the direct construction of β-keto sulfones using a wide variety of keto and sulfonyl precursors. Of note, the most promising photoredox transformations and electrochemical synthesis methods of β-keto sulfones are also presented. Moreover, β-keto sulfones are versatile building blocks in organic synthesis due to their three essential functional groups: sulfonyl, carbonyl, and active methylene moieties. The convenient preparation of β-keto sulfones allows the synthesis of many valuable carbocyclic and heterocyclic compounds, and the effortless removal of the sulfonyl moiety via transformations is supported. The chemistry of β-keto sulfones (2013 to present) can be divided into several sections based on the sulfonyl surrogates, and ubiquitous synthetic strategies were systematically outlined.
这篇综述主要关注 β-酮亚砜的制备及其广泛的合成应用的最新进展。还强调了β-酮硫砜合成的新前景。在过去的十年中，使用各种酮和砜基前体直接构建β-酮亚砜的方法得到了快速发展。值得注意的是，还介绍了最有前途的光氧化还原转化和β-酮亚砜的电化学合成方法。此外，由于β-酮亚砜具有三个重要的官能团：砜基、羰基和活泼亚甲基，因此它是有机合成中的多功能构建块。β-酮亚砜的方便制备允许合成许多有价值的碳环和杂环化合物，并且通过转化可以轻松去除砜基部分。β-酮亚砜的化学（2013 年至今）可以根据砜基取代基分为几个部分，并系统地概述了普遍存在的合成策略。
