Huang B-S, Wu S-C, Lin C-Y, Fan K-H, Chang J T-C, Chen S-C
Department of Radiation Oncology, Chang Gung Medical Foundation, Proton and Radiation Therapy Center, Linkou Chang Gung Memorial Hospital, Taoyuan, Taiwan.
Department of Medicine, College of Medicine, Chang Gung University, Taoyuan, Taiwan.
Eur J Cancer Care (Engl). 2018 Mar;27(2):e12819. doi: 10.1111/ecc.12819. Epub 2018 Jan 9.
Radiation therapy (RT) and concurrent chemotherapy RT (CCRT) generate radiation-induced oral mucositis (OM) and lower quality of life (QOL). This study assessed the impact of a saline mouth rinse regimen and education programme on radiation-induced OM symptoms, and QOL in oral cavity cancer (OCC) patients receiving RT or CCRT. Ninety-one OCC patients were randomly divided into a group that received saline mouth rinses and an education programme and a control group that received standard care. OM symptoms and QOL were assessed with the WHO Oral Toxicity Scale, MSS-moo and UW-QOL. Data were collected at the first postoperative visit to the radiation department (T0) and at 4 weeks and 8 weeks after beginning RT or CCRT. Patients in both groups had significantly higher levels of physical and social-emotional QOL at 8 weeks after beginning RT or CCRT compared to the first visit. Patients in the saline rinse group had significantly better physical and social-emotional QOL as compared to the standard care group at 8 weeks. Radiation-induced OM symptoms and overall QOL were not different between the groups. We thus conclude the saline rinse and education programme promote better physical and social-emotional QOL in OCC patients receiving RT/CCRT.
放射治疗（RT）和同步放化疗（CCRT）会引发放射性口腔黏膜炎（OM）并降低生活质量（QOL）。本研究评估了盐水漱口方案和教育计划对接受RT或CCRT的口腔癌（OCC）患者放射性OM症状及生活质量的影响。91例OCC患者被随机分为接受盐水漱口和教育计划的组以及接受标准护理的对照组。采用世界卫生组织口腔毒性量表、MSS - moo和UW - QOL评估OM症状和生活质量。在术后首次到放疗科就诊时（T0）以及开始RT或CCRT后的4周和8周收集数据。与首次就诊相比，两组患者在开始RT或CCRT后的8周时身体和社会情感生活质量水平均显著更高。在8周时，盐水漱口组患者的身体和社会情感生活质量明显优于标准护理组。两组之间放射性OM症状和总体生活质量无差异。因此，我们得出结论，盐水漱口和教育计划可使接受RT/CCRT的OCC患者获得更好的身体和社会情感生活质量。
