Unit of Food Science and Nutrition, Università Campus Bio-Medico di Roma, Via Alvaro del Portillo 21, 00128 Rome, Italy.
Research Unit of Gastroenterology, Università Campus Biomedico di Roma, Via Alvaro del Portillo 21, 00128 Rome, Italy.
Nutrients. 2022 Dec 17;14(24):5374. doi: 10.3390/nu14245374.
In recent years, evidence has shown the potential therapeutic effects of different natural compounds for the prevention and treatment of radiotherapy-induced mucositis (RIOM). RIOM represents one of the most frequent side effects associated with anti-neoplastic treatments affecting patients' quality of life and treatment response due to radiation therapy discontinuation. The innate radio-protective ability of natural products obtained from plants is in part due to the numerous antioxidants possessed as a part of their normal secondary metabolic processes. However, oxygen presence is a key point for radiation efficacy on cancer cells. The aim of this review is to describe the most recent evidence on radiation-induced injury and the emerging protective role of natural compounds in preventing and treating this specific damage without compromising treatment efficacy.
近年来，有证据表明，不同的天然化合物在预防和治疗放射性粘膜炎（RIOM）方面具有潜在的治疗作用。RIOM 是抗肿瘤治疗中最常见的副作用之一，由于放疗中断，会影响患者的生活质量和治疗反应。植物中天然产物的先天放射保护能力部分归因于它们正常的次生代谢过程中所具有的众多抗氧化剂。然而，氧气的存在是辐射对癌细胞产生疗效的关键。本综述的目的是描述放射诱导损伤的最新证据，以及天然化合物在预防和治疗这种特定损伤而不影响治疗效果方面的新兴保护作用。
