DST-CSIR National Centre for Nanostructured Materials, Council for Scientific and Industrial Research, Pretoria, 0001, South Africa.
Department of Applied Chemistry, University of Johannesburg, Droonfontein, 2028, Johannesburg, South Africa.
Chem Rec. 2018 Jul;18(7-8):913-927. doi: 10.1002/tcr.201700080. Epub 2018 Jan 9.
The chemical stability, degradation and penetration ability of pharmaceutically active ingredients in topical formulations are the greatest challenges because of problems with the protection of actives for long times and with delivery. Therefore, the development of unique and efficient substrate material is vital for their protection and controlled drug release. Layered double hydroxides (LDHs) known as hydrotalcite like compounds possess positive charges due to isomorphic substitutions, which are counterbalanced by hydrated exchangeable anions located in the interlayer region. Some of the active ingredient molecules can be intercalated into the inner region of the LDHs through ionic bonding, hydrogen bonding or van der Waals interaction to form nanohybrids, which are more potent for their protection and controlled-release. This account focuses on our recent research efforts and key scientific and technical challenges in the development of LDH based nanohybrids for commercial use in advanced controlled release carriers of active ingredients in topical formulations.
由于长时间保护药物活性成分和药物传递方面存在问题，药物制剂中药物活性成分的化学稳定性、降解和渗透能力是最大的挑战。因此，开发独特而有效的基质材料对于保护和控制药物释放至关重要。层状双氢氧化物（LDHs）被称为类水滑石化合物，由于同晶取代而具有正电荷，这些正电荷被位于层间区域的水合可交换阴离子所平衡。一些活性成分分子可以通过离子键、氢键或范德华相互作用插入 LDHs 的内层区域，形成纳米复合材料，这对于它们的保护和控制释放更为有效。本报告重点介绍了我们在基于 LDH 的纳米复合材料的开发方面的最新研究进展，以及在将其开发为药物制剂中活性成分的高级控释载体方面的关键科学和技术挑战。
