Pazos A, Stoeckel M E, Hindelang C, Palacios J M
Neurosci Lett. 1985 Aug 16;59(1):1-7. doi: 10.1016/0304-3940(85)90206-x.
The influence of the estrous cycle on the density of dopamine D2 sites in the rat pituitary was studied by quantitative autoradiography using [3H]spiperone. While no significant changes were found in the neural and intermediate lobes during the cycle, a lower number of D2 receptors in the anterior lobe was observed in the proestrus when compared to the diestrus. The difference in the density of [3H]spiperone binding in the pituitary between male and female rats was also analysed. A significantly lower number of receptors in the three lobes of the male pituitary, as compared to those of the female, was found. Finally, no significant variation in the number of binding sites in the 3 pituitary lobes was observed between lactating and separated mothers.
采用[3H]司哌隆通过定量放射自显影术研究了发情周期对大鼠垂体中多巴胺D2位点密度的影响。在整个周期中，神经叶和中间叶未发现显著变化，但与动情间期相比，发情前期前叶中的D2受体数量较少。还分析了雄性和雌性大鼠垂体中[3H]司哌隆结合密度的差异。结果发现，雄性垂体三个叶中的受体数量明显低于雌性。最后，在泌乳母鼠和分窝母鼠的垂体三个叶中，未观察到结合位点数量的显著差异。
