De Souza E B, Kuhar M J
Brain Res. 1984 Jul 23;306(1-2):391-5. doi: 10.1016/0006-8993(84)90394-9.
We examined the distribution of dopamine and serotonin receptors in human pituitary gland by light microscopic autoradiography using [3H]spiperone as a binding ligand. Clusters of specific binding sites for [3H]spiperone were observed in the anterior pituitary. This clustering is similar to the clustering of lactotrophs observed in immunohistochemical studies. No specific binding sites for [3H]spiperone were present in the posterior lobe of the pituitary gland. We found no evidence for the presence of serotonin-2 receptors (i.e. cinanserin-displaceable [3H]spiperone binding) in human pituitary.
我们使用[3H]螺哌隆作为结合配体，通过光学显微镜放射自显影术研究了多巴胺和5-羟色胺受体在人垂体中的分布。在前叶垂体中观察到了[3H]螺哌隆特异性结合位点的簇集。这种簇集类似于免疫组织化学研究中观察到的催乳细胞的簇集。垂体后叶中不存在[3H]螺哌隆的特异性结合位点。我们没有发现人垂体中存在5-羟色胺-2受体（即辛那色林可置换的[3H]螺哌隆结合）的证据。
