Head, Pathology and Laboratory Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.
Cancer Cell. 2018 Jan 8;33(1):7-9. doi: 10.1016/j.ccell.2017.12.010.
In this issue of Cancer Cell, Yaeger et al. report mutations, copy number variations, and selected rearrangements from a large series of metastatic colorectal carcinomas and primaries that produced metastases. The results provide important insights into differences in anatomical site of origin, age at onset, etiologic factors, and therapeutic responses.
在本期《癌细胞》杂志中，Yaeger 等人报道了一系列来自转移性结直肠癌和产生转移的原发性肿瘤的大量突变、拷贝数变异和选择性重排。这些结果为解剖起源部位、发病年龄、病因因素和治疗反应的差异提供了重要的见解。
