Department of Fundamental Neurosciences, University of Lausanne, CH-1005 Lausanne, Switzerland.
Department of Fundamental Neurosciences, University of Lausanne, CH-1005 Lausanne, Switzerland.
Curr Opin Neurobiol. 2018 Feb;48:139-145. doi: 10.1016/j.conb.2017.12.014. Epub 2018 Jan 6.
Astrocytes, the largest glial population in human and murine brains, are crucial to the regulation of synaptic connectivity. During the first three weeks of postnatal development, immature astrocytes express mGlu5 and expands several fold while undergoing a transition towards their mature phase. Although mGlu5-mediated signalling in astrocyte functions has been extensively studied in the last decades, whether this signalling is implicated in the mechanisms governing their development, as well as the effects of dysregulated astrocytic development on neurodevelopmental disorders, are still unclear. The aim of this review is to examine what is known about the mGlu5-mediated signalling in the developing astrocytes and its possible contribution to the pathophysiology of autism spectrum disorders.
星形胶质细胞是人类和鼠脑中最大的神经胶质细胞群体，对调节突触连接至关重要。在出生后三周的发育过程中，未成熟的星形胶质细胞表达 mGlu5 并扩展数倍，同时向成熟阶段过渡。尽管 mGlu5 介导的星形胶质细胞功能信号在过去几十年中得到了广泛研究，但这种信号是否参与调节其发育的机制，以及星形胶质细胞发育失调对神经发育障碍的影响仍不清楚。本综述的目的是研究 mGlu5 介导的信号在发育中的星形胶质细胞中的作用及其对自闭症谱系障碍病理生理学的可能贡献。
