Department of Neurology, Albany Medical Center, Albany, NY, United States.
Department of Neurology, Albany Medical Center, Albany, NY, United States.
J Neuroimmunol. 2018 Mar 15;316:130-132. doi: 10.1016/j.jneuroim.2018.01.003. Epub 2018 Jan 3.
Neuromyelitis optic spectrum disorders are demyelinating conditions that are typically idiopathic, though various case reports have demonstrated an association with malignancy. We present the case of a 64year old woman with NMOSD in the setting of small cell lung cancer. She had longitudinally extensive transverse myelitis and left eye optic neuritis; aquaporin-4 antibodies were elevated. Biopsy of mediastinal adenopathy was positive for SCLC. Malignancy should be considered in any patient with an atypical presentation of NMOSD, or who does not respond to traditional therapies.
视神经脊髓炎谱系疾病是脱髓鞘疾病，通常为特发性，但各种病例报告表明其与恶性肿瘤有关。我们报告了一例小细胞肺癌伴 NMOSD 的 64 岁女性病例。她患有长节段横贯性脊髓炎和左眼视神经炎；水通道蛋白-4 抗体升高。纵隔淋巴结活检阳性，符合小细胞肺癌。任何 NMOSD 表现不典型或对传统治疗无反应的患者均应考虑恶性肿瘤的可能。
