Department of Urology, Sanjay Gandhi Postgraduate Institute of Medical Sciences (SGPGIMS), Lucknow, India; Department of Biosciences, Integral University, Lucknow, India.
Department of Cardiology, Sanjay Gandhi Postgraduate Institute of Medical Sciences (SGPGIMS), Lucknow, India.
Immunol Lett. 2018 Feb;194:69-78. doi: 10.1016/j.imlet.2018.01.001. Epub 2018 Jan 6.
RHD is an inflammatory disease resulting from interactive immune, genetic, and environmental factors. Various, epidemiological studies have shown the association of genetic variants of cytokine genes with a predisposition to RHD. However, the results from different populations are inconsistent. Therefore, we carried out a meta- analysis of twenty-three published case-control studies and the results indicated that TGF-β1 +869 T/C (T vs. C: OR = 7.68, 95% CI = 1.62-36.50; TT + CT vs. CC OR = 1.83, 95%CI = 1.39-2.41), TGF-β1-509 (T vs. C: OR = 2.76, 95% CI = 1.33-5.75), TNF-α(AA vs. GG: OR = 4.93,95% CI = 2.83-8.58; A vs. G: OR = 2.15, 95% CI = 1.13-4.12) and IL-1β -511C/T (CC + CT vs. TT: OR = 1.35, 95%CI = 1.02-1.78; C vs. T: OR = 2.36, 95% CI = 1.66-3.37) were significantly associated with increased risk of RHD. On the other hand, IL-10(-1082)G/A polymorphism (GA vs. AA: OR = 0.91, 95% CI = 0.36-2.33; G vs. A: OR = 1.90, 95% CI = 0.58-6.22) and IL-6-174 G/C (CC + GC vs. GG: OR = 0.68, 95%CI = 0.32-1, C vs. G: OR = 1.14, 95% CI = 0.82-1.60) were not associated with modified RHD risk. The meta-analysis results were similar in Asians and non-Asians. Therefore, cytokine gene polymorphisms play important role in the genetic susceptibility of RHD in rheumatic fever patients.
RHD 是一种由免疫、遗传和环境因素相互作用引起的炎症性疾病。各种流行病学研究表明，细胞因子基因的遗传变异与 RHD 的易感性有关。然而，来自不同人群的结果并不一致。因此，我们进行了一项荟萃分析，共纳入了 23 项已发表的病例对照研究，结果表明 TGF-β1+869T/C（T 对 C：OR=7.68，95%CI=1.62-36.50；TT+CT 对 CC：OR=1.83，95%CI=1.39-2.41）、TGF-β1-509（T 对 C：OR=2.76，95%CI=1.33-5.75）、TNF-α（AA 对 GG：OR=4.93，95%CI=2.83-8.58；A 对 G：OR=2.15，95%CI=1.13-4.12）和 IL-1β-511C/T（CC+CT 对 TT：OR=1.35，95%CI=1.02-1.78；C 对 T：OR=2.36，95%CI=1.66-3.37）与 RHD 风险增加显著相关。另一方面，IL-10-1082G/A 多态性（GA 对 AA：OR=0.91，95%CI=0.36-2.33；G 对 A：OR=1.90，95%CI=0.58-6.22）和 IL-6-174G/C（CC+GC 对 GG：OR=0.68，95%CI=0.32-1，C 对 G：OR=1.14，95%CI=0.82-1.60）与修正后的 RHD 风险无关。荟萃分析结果在亚洲人和非亚洲人之间相似。因此，细胞因子基因多态性在风湿热患者 RHD 的遗传易感性中起重要作用。
