Division of Developmental Cognitive Neuroscience, Institute of Development, Aging and Cancer, Tohoku University, Sendai, Japan.
Division of Medical Neuroimaging Analysis, Department of Community Medical Supports, Tohoku Medical Megabank Organization, Tohoku University, Sendai, Japan.
Sci Rep. 2018 Jan 9;8(1):175. doi: 10.1038/s41598-017-18669-0.
Myopia is part of the spectrum of refractive error. Myopia is associated with psychometric intelligence and, the link between brain anatomy and myopia has been hypothesized. Here we aimed to identify the associations between brain structures and refractive error in developed young adults. In a study cohort of 1,319 normal educated young adults, the refractive error showed a significant negative correlation with total intracranial volume and total cerebrospinal fluid (CSF) volume but not with total gray matter volume (GMV) or total white matter volume (WMV). Time spent studying was associated with refractive error but could not explain the aforementioned associations with brain volume parameters. The R values of the simple regression between spherical equivalent and outcome variables for each sex in non-whole brain imaging analyses were less than 0.05 in all cases and thus were weak. Psychometric intelligence was not associated with refractive error or total CSF volume, but it weakly positively correlated with total GMV and total WMV in this study population. Thus, refractive error appears to be primarily (weakly) associated with the volume of the cranium, whereas psychometric intelligence was associated with the volume of the brain.
近视是屈光不正的一部分。近视与心理计量智力有关，并且已经假设了大脑解剖结构与近视之间的联系。在这里，我们旨在确定在已开发的年轻成年人中，大脑结构与屈光不正之间的关联。在一项由 1319 名受过良好教育的正常年轻人组成的研究队列中，屈光不正与总颅内体积和总脑脊液 (CSF) 体积呈显著负相关，但与总灰质体积 (GMV) 或总白质体积 (WMV) 无关。学习时间与屈光不正有关，但不能解释与大脑体积参数的上述关联。在非全脑成像分析中，每个性别之间的球镜等效物与结果变量之间的简单回归的 R 值在所有情况下均小于 0.05，因此较弱。在本研究人群中，心理计量智力与屈光不正或总 CSF 体积无关，但与总 GMV 和总 WMV 呈弱正相关。因此，屈光不正似乎主要（弱）与颅骨体积有关，而心理计量智力与大脑体积有关。
