Opris Ioan, Nestianu Valeriu S, Nestianu Adrian, Bilteanu Liviu, Ciurea Jean
Miller School of Medicine, University of Miami, Miami, FL, United States.
University of Medicine and Pharmacy of Craiova, Craiova, Romania.
Front Neurosci. 2017 Dec 25;11:726. doi: 10.3389/fnins.2017.00726. eCollection 2017.
George Marinesco is the founder of Romanian School of Neurology and one of the most remarkable neuroscientists of the last century. He was the pupil of Jean-Martin Charcot in Salpêtrière Hospital in Paris, France, but visited many other neurological centers where he met the entire constellation of neurologists of his time, including Camillo Golgi and Santiago Ramón y Cajal. The last made the preface of Nervous Cell, written in French by Marinesco. The original title was "La Cellule Nerveuse" and is considered even now a basic reference book for specialists in the field. He was a refined clinical observer with an integrative approach, as could be seen from the multitude of his discoveries. The descriptions of the succulent hand in syringomyelia, senile plaque in old subjects, palmar jaw reflex known as Marinesco-Radovici sign, or the application of cinematography in medicine are some of his important contributions. He was the first who described changes of locus niger in a patient affected by tuberculosis, as a possible cause in Parkinson disease. Before modern genetics, Marinesco and Sjögren described a rare and complex syndrome bearing their names. He was a hardworking man, focused on his scientific research, did not accepted flattering of others and was a great fighter against the injustice of the time.
乔治·马里内斯科是罗马尼亚神经学派的创始人,也是上世纪最杰出的神经科学家之一。他曾是法国巴黎萨尔佩特里埃医院让 - 马丁·沙尔科的学生,但他还访问过许多其他神经学中心,在那里他结识了当时所有的神经学家,包括卡米洛·高尔基和圣地亚哥·拉蒙·伊·卡哈尔。后者为马里内斯科用法语撰写的《神经细胞》作了前言。该书原名《La Cellule Nerveuse》,即便在如今,仍被视为该领域专家的一本基础参考书。他是一位有着综合方法的精细临床观察者,从他众多的发现中可见一斑。他对脊髓空洞症中肉质手的描述、老年患者中的老年斑、以马里内斯科 - 拉多维奇征闻名的掌颌反射,或者医学中电影摄影术的应用,都是他的一些重要贡献。他是第一个描述肺结核患者黑质变化的人,认为这可能是帕金森病的一个病因。在现代遗传学出现之前,马里内斯科和舍格伦描述了一种以他们名字命名的罕见而复杂的综合征。他是一个勤奋的人,专注于科学研究,不接受他人的奉承,是当时不公正现象的伟大抗争者。