Chaudhuri Saikat, Ghosh Santanu, Bhunia Subhajit, Bisai Alakesh
Department of Chemistry, Indian Institute of Science Education and Research Bhopal, Bhauri, Bhopal - 462 066, Madhya Pradesh, India.
Chem Commun (Camb). 2018 Jan 23;54(8):940-943. doi: 10.1039/c7cc09045e.
We report an expeditious catalytic asymmetric approach to clavine alkaloids via a key Heck cyclization. This reaction sets the formation of vicinal stereocenters with excellent diastereoselectivity. Utilizing the aforementioned strategy, the formal total synthesis of cycloclavine (1) has been achieved via another key late-stage ester-aminolysis of 6.
我们报道了一种通过关键的Heck环化反应快速合成麦角碱类生物碱的催化不对称方法。该反应以优异的非对映选择性构建了相邻的立体中心。利用上述策略,通过另一个关键的后期6的酯氨解反应,实现了环麦角碱(1)的形式全合成。