Mylonas S, Brunkwall S, Brunkwall J
Klinik und Poliklinik für Gefäßchirurgie und Endovaskuläre Chirurgie, Universitätsklinikum, Universität zu Köln, Kerpener Str. 62, 50937, Köln, Deutschland.
Chirurg. 2018 Apr;89(4):319-330. doi: 10.1007/s00104-017-0572-3.
Vascular malformations are congenital vascular anomalies with normal endothelial turnover, which can affect the whole vessel tree (arterial, capillary or lymphatic) both as isolated defects or as part of a syndrome. Developmental errors during embryogenesis, such as abnormal signaling processes that control the apoptosis, maturation and growth of vascular cells, lead to the persistence of vascular plexus cells with some degree of differentiation. Vascular malformations are usually present at birth, although symptoms or complications may be manifested later. Since the overwhelming majority are symptomatic, treatment is indicated which is often aimed only at improving the symptoms by controlling the size.
血管畸形是先天性血管异常,内皮细胞更新正常,可作为孤立缺陷或作为综合征的一部分影响整个血管系统(动脉、毛细血管或淋巴管)。胚胎发育过程中的发育错误,如控制血管细胞凋亡、成熟和生长的异常信号传导过程,导致具有一定程度分化的血管丛细胞持续存在。血管畸形通常在出生时就存在,尽管症状或并发症可能在以后出现。由于绝大多数血管畸形有症状,因此需要进行治疗,治疗通常仅旨在通过控制大小来改善症状。