Laboratory for Chromosome Segregation, RIKEN Center for Developmental Biology, Kobe, 650-0047, Japan.
Dev Growth Differ. 2018 Jan;60(1):33-43. doi: 10.1111/dgd.12410. Epub 2018 Jan 10.
Proper kinetochore-microtubule attachment is essential for correct chromosome segregation. Therefore, cells normally possess multiple mechanisms for the prevention of errors in kinetochore-microtubule attachments and for selective stabilization of correct attachments. However, the oocyte, a cell that produces an egg through meiosis, exhibits a high frequency of errors in kinetochore-microtubule attachments. These attachment errors predispose oocytes to chromosome segregation errors, resulting in aneuploidy in eggs. This review aims to provide possible explanations for the error-prone nature of oocytes by examining key differences among other cell types in the mechanisms for the establishment of kinetochore-microtubule attachments.
正确的着丝粒-微管附着对于正确的染色体分离至关重要。因此，细胞通常具有多种机制来防止着丝粒-微管附着错误，并选择性地稳定正确的附着。然而，卵母细胞，即通过减数分裂产生卵子的细胞，表现出着丝粒-微管附着错误的高频率。这些附着错误使卵母细胞容易发生染色体分离错误，导致卵子的非整倍体。本综述旨在通过检查其他细胞类型在建立着丝粒-微管附着的机制方面的关键差异，为卵母细胞易出错的性质提供可能的解释。
