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心脏骤停后植入式心律转复除颤器植入的趋势及预测因素:来自全国住院患者样本的见解

Trends and predictors of implantable cardioverter defibrillator implantation after sudden cardiac arrest: Insight from the national inpatient sample.

作者信息

Munir Muhammad Bilal, Alqahtani Fahad, Aljohani Sami, Bhirud Ashwin, Modi Sujal, Alkhouli Mohamad

机构信息

West Virginia University Heart & Vascular Institute, Morgantown, WV, USA.

出版信息

Pacing Clin Electrophysiol. 2018 Mar;41(3):229-237. doi: 10.1111/pace.13274. Epub 2018 Feb 12.

Abstract

BACKGROUND

Implantable cardioverter defibrillator (ICD) has a class IA indication in survivors of sudden cardiac arrest (SCA) provided no reversible cause is identified. We sought to determine trends and predictors of ICD implant in SCA patients from a national sample of the United States population.

METHODS AND RESULTS

Data were gathered from National Inpatient Sample (NIS) from January 2003 to December 2014. All patients ≥18 years of age with a primary discharge diagnosis of SCA, ventricular fibrillation (VF), ventricular flutter, and ventricular tachycardia (VT) were included. Patients died during hospitalization, had a previous ICD implant, and with a reversible cause of SCA were excluded. Primary outcome of interest was rate of new ICD implant at discharge. Logistic regression analysis was then performed to determine predictors for ICD implantation. A total of 176,876 patients were identified to have SCA, VF, ventricular flutter, and VT. After applying exclusion criteria, we were left with 22,054 patients. Out of this, 6,908 (31%) patients were implanted with an ICD prior to discharge. There was a linear trend toward reduced ICD utilization over our study period (40% in 2003 vs 25% in 2014, P trend = 0.0004). Advanced age, black race, and chronic renal disease are independently associated with low ICD utilization.

CONCLUSION

We found low trend of ICD implant in survivors of SCA without any reversible cause. There is a need to identify etiologies behind low ICD utilization in this vulnerable group who are at most risk for a subsequent SCA.

摘要

背景

对于心脏骤停(SCA)幸存者,若未发现可逆性病因,植入式心律转复除颤器(ICD)有ⅠA级适应症。我们试图从美国全国人口样本中确定SCA患者植入ICD的趋势及预测因素。

方法与结果

收集2003年1月至2014年12月期间美国国家住院样本(NIS)的数据。纳入所有年龄≥18岁、主要出院诊断为SCA、室颤(VF)、室扑和室性心动过速(VT)的患者。排除住院期间死亡、既往已植入ICD以及有可逆性SCA病因的患者。主要关注结局是出院时新植入ICD的比例。然后进行逻辑回归分析以确定ICD植入的预测因素。共有176,876例患者被确定患有SCA、VF、室扑和VT。应用排除标准后,剩余22,054例患者。其中,6,908例(31%)患者在出院前植入了ICD。在我们的研究期间,ICD的使用呈线性下降趋势(2003年为40%,2014年为25%,P趋势=0.0004)。高龄、黑人种族和慢性肾病与ICD低使用率独立相关。

结论

我们发现无任何可逆病因的SCA幸存者中ICD植入率较低。有必要确定这一极易发生后续SCA的弱势群体中ICD低使用率背后的病因。

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