Department of Obstetrics & Gynecology, The Affiliated Hospital of Jiangnan University, Wuxi 214062, China.
Department of Obstetrics & Gynecology, Yantai Yuhuangding Hospital Affiliated to Medical College of Qingdao University, Yantai 264000, China.
Future Oncol. 2018 Feb;14(3):241-253. doi: 10.2217/fon-2017-0474. Epub 2018 Jan 10.
We aim to investigate the functions of PXN in cervical cancer.
MATERIALS & METHODS: PXN protein was investigated by immunohistochemistry in a panel of cervical cancer. A series of in vitro and in vivo assays were used to explore the efficacy of PXN.
PXN was significantly upregulated in cervical cancer, which associated with tumor stage, poor differentiation, lymphovascular space invasion and lymphatic metastasis. Knockdown of PXN notably impaired cellular growth and colony formation by suppressing Bcl-2 and inducing marked apoptosis. Moreover, PXN led to resistance to radiation, and downregulation of PXN resensitized C33A cells to radiation.
PXN was frequently upregulated and acted as an oncogene via regulating Bcl-2 in cervical cancer, which supports PXN as a potent therapeutic target.
研究 PXN 在宫颈癌中的功能。
采用免疫组织化学方法检测宫颈癌中 PXN 蛋白的表达。通过一系列体外和体内实验来探讨 PXN 的作用。
PXN 在宫颈癌中显著上调，与肿瘤分期、低分化、淋巴血管空间浸润和淋巴转移有关。敲低 PXN 通过抑制 Bcl-2 和诱导明显的细胞凋亡显著抑制细胞生长和集落形成。此外，PXN 导致放射抵抗，下调 PXN 可使 C33A 细胞对放射敏感。
PXN 在宫颈癌中频繁上调，通过调节 Bcl-2 发挥癌基因作用，支持 PXN 作为一种有效的治疗靶点。
