Zhou Junying, Lei Ningjing, Tian Wanjia, Guo Ruixia, Chen Mengyu, Qiu Luojie, Wu Fengling, Li Yong, Chang Lei
Department of Obstetrics and Gynecology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China.
School of Basic Medical Sciences, Zhengzhou University, Zhengzhou, China.
Front Oncol. 2022 Oct 12;12:999643. doi: 10.3389/fonc.2022.999643. eCollection 2022.
Radiotherapy is widely used as an indispensable treatment option for cervical cancer patients. However, radioresistance always occurs and has become a big obstacle to treatment efficacy. The reason for radioresistance is mainly attributed to the high repair ability of tumor cells that overcome the DNA damage caused by radiotherapy, and the increased self-healing ability of cancer stem cells (CSCs). Accumulating findings have demonstrated that the tumor microenvironment (TME) is closely related to cervical cancer radioresistance in many aspects, especially in the metabolic processes. In this review, we discuss radiotherapy in cervical cancer radioresistance, and focus on recent research progress of the TME metabolism that affects radioresistance in cervical cancer. Understanding the mechanism of metabolism in cervical cancer radioresistance may help identify useful therapeutic targets for developing novel therapy, overcome radioresistance and improve the efficacy of radiotherapy in clinics and quality of life of patients.
放射治疗作为宫颈癌患者不可或缺的治疗选择被广泛应用。然而，放射抗性总是会出现，并已成为治疗效果的一大障碍。放射抗性的原因主要归因于肿瘤细胞具有较高的修复能力，能够克服放疗引起的DNA损伤，以及癌症干细胞（CSCs）自我修复能力的增强。越来越多的研究结果表明，肿瘤微环境（TME）在许多方面与宫颈癌放射抗性密切相关，尤其是在代谢过程中。在本综述中，我们讨论了宫颈癌放射抗性中的放射治疗，并重点关注影响宫颈癌放射抗性的TME代谢的最新研究进展。了解宫颈癌放射抗性中的代谢机制可能有助于确定开发新疗法的有用治疗靶点，克服放射抗性，提高临床放疗效果和患者生活质量。
