Xie Shangchen, Ma Wenjuan, Guo Qulian, Liu Jie, Li Wei, McLeod Howard L, He Yijing
Department of Clinical Pharmacology, Xiangya Hospital, Central South University, Institute of Clinical Pharmacology, Central South University, Hunan Key Laboratory of Pharmacogenetics, Changsha, Hunan, P.R. China.
Department of Anesthesiology, Xiangya Hospital, Central South University, Changsha, Hunan, P.R. China.
Pharmacogenomics. 2018 Feb;19(3):285-298. doi: 10.2217/pgs-2017-0168. Epub 2018 Jan 10.
General anesthesia is a state of unconsciousness, amnesia, analgesia and akinesia induced by drugs including opioids, hypnotic-sedative agents, muscle relaxants and antiemetics. Clinical and genetic factors are reported to influence the efficacy and side effects of these agents. Based on the evidence, clinical action is needed to improve clinical outcomes. This review summarizes the latest knowledge with regards to the pharmacogenetics of anesthetics and general anesthesia related complications.
全身麻醉是一种由包括阿片类药物、催眠镇静剂、肌肉松弛剂和止吐药在内的药物诱导产生的无意识、失忆、镇痛和运动不能状态。据报道，临床和遗传因素会影响这些药物的疗效和副作用。基于这些证据，需要采取临床行动来改善临床结局。本综述总结了关于麻醉药的药物遗传学以及全身麻醉相关并发症的最新知识。
