Mukhopadhyay Soumendranath, Pan Subhas Chandra
Department of Chemistry, Indian Institute of Technology, Guwahati, 781039, India.
Chem Commun (Camb). 2018 Jan 23;54(8):964-967. doi: 10.1039/c7cc08338f.
The first highly diastereo- and enantioselective synthesis of 2,4-disubstituted imidazolidines has been developed via a formal [3+2] cyclization reaction. Bidentate aminomethyl enones and N-tosyl imines were used as the reaction partners in the reaction. Bifunctional squaramide catalysts were found to be efficient for this reaction and few transformations of the products have been demonstrated.
通过形式上的[3+2]环化反应，首次实现了2,4-二取代咪唑烷的高非对映选择性和对映选择性合成。在该反应中，使用双齿氨甲基烯酮和N-甲苯磺酰基亚胺作为反应底物。发现双功能方酰胺催化剂对该反应有效，并且已证明产物的少量转化。
