使用专门设计的新型 N-杂环卡宾催化剂实现高化学选择性的分子间交叉苯偶姻反应。
Highly chemoselective intermolecular cross-benzoin reactions using an ad hoc designed novel N-heterocyclic carbene catalyst.
机构信息
School of Chemistry Trinity Biomedical Sciences Institute, Trinity College Dublin, 152-160 Pearse Street, Dublin 2, Ireland.
出版信息
Org Biomol Chem. 2018 Jan 31;16(5):780-786. doi: 10.1039/c7ob03005c.
PMID:29319099
Abstract
The design of a novel N-heterocyclic carbene catalyst incorporating a bulky yet highly electron-deficient N-aryl substituent has allowed the development of an efficient protocol for the first highly chemoselective intermolecular benzoin condensations between two non-identical aromatic aldehydes.
摘要
新型 N-杂环卡宾催化剂的设计结合了一个庞大但高度缺电子的 N-芳基取代基，这使得开发出一种高效的协议成为可能，用于首次在两个非等同的芳族醛之间进行高度选择性的分子间安息香缩合反应。
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