21三体胎儿羊水、羊膜细胞和成纤维细胞中的免疫反应性超氧化物歧化酶-1
Immunoreactive SOD-1 in amniotic fluid, amniotic cells and fibroblasts from trisomy 21 fetus.
作者信息
Baeteman M A, Mattei M G, Baret A, Gamerre M, Mattei J F
出版信息
Acta Paediatr Scand. 1985 Sep;74(5):697-700. doi: 10.1111/j.1651-2227.1985.tb10016.x.
Abstract
Copper superoxide dismutase (Cu-SOD or SOD-1) was measured by radioimmunoassay (RIA) in amniotic cells and fluid as well as in fetal trisomy 21 fibroblasts. The significant increase of the SOD-1 activity observed in amniotic cells and fetal trisomy 21 fibroblasts demonstrates the early physiopathogenic expression of the supernumerary chromosome 21 in affected patients.
摘要
通过放射免疫分析（RIA）测定了羊膜细胞、羊水以及21三体胎儿成纤维细胞中的铜超氧化物歧化酶（Cu-SOD或SOD-1）。在羊膜细胞和21三体胎儿成纤维细胞中观察到的SOD-1活性显著增加，证明了21号多余染色体在受影响患者中的早期病理生理表达。
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