唐氏综合征中羊水胎盘碱性磷酸酶水平较低。

Low levels of amniotic fluid placental alkaline phosphatase in Down's syndrome.

作者信息

Ind T E, Iles R K, Wathen N C, Murugan P, Campbell J, Macintosh M, Chard T

机构信息

Department of Obstetrics, Gynaecology, St. Bartholomew's Hospital, London, UK.

出版信息

Br J Obstet Gynaecol. 1993 Sep;100(9):847-9. doi: 10.1111/j.1471-0528.1993.tb14312.x.

DOI:10.1111/j.1471-0528.1993.tb14312.x

PMID:8218007

Abstract

OBJECTIVE

To investigate amniotic fluid placental alkaline phosphatase (PLAP) levels in normal and trisomy 21 pregnancies.

DESIGN

Cross sectional study.

SETTING

A tertiary referral prenatal diagnostic service.

SUBJECTS

Three hundred and eleven women with singleton pregnancies of normal karyotype between 10 and 23 weeks gestation and 31 women with pregnancies associated with trisomy 21 Down's syndrome.

OUTCOME MEASURES

PLAP levels were measured by immunoradiometric assay in amniotic fluid obtained by amniocentesis.

RESULTS

Amniotic fluid PLAP was detectable from 12 weeks gestation and the median value rose to a peak of 4.57 iu/l at 18 weeks. Pregnancies associated with Down's syndrome had significantly lower levels with a median multiple of median (MoM) of 0.638, (U = 3374, P = 0.0016, 95% CI = 0.50, 0.89). For the 20 women with trisomy 21 pregnancies detected at 16 to 18 weeks, the median MoM was 0.482, (U = 3694, P = 0.0011, 95% CI = 0.37, 0.85).

CONCLUSION

These data demonstrates that PLAP levels are reduced in the amniotic fluid of women carrying a fetus with trisomy 21.

摘要

目的

研究正常妊娠和21三体妊娠中羊水胎盘碱性磷酸酶（PLAP）水平。

设计

横断面研究。

地点

一家三级转诊产前诊断服务机构。

研究对象

311名单胎妊娠、核型正常且孕周在10至23周之间的女性，以及31名与21三体唐氏综合征相关妊娠的女性。

观察指标

通过免疫放射分析测定羊膜穿刺术获取的羊水中的PLAP水平。

结果

妊娠12周时可检测到羊水PLAP，其在妊娠18周时中位数升至峰值4.57 iu/l。唐氏综合征相关妊娠的PLAP水平显著较低，中位数倍数（MoM）为0.638，（U = 3374，P = 0.0016，95%可信区间 = 0.50，0.89）。对于在16至18周检测出21三体妊娠的20名女性，中位数MoM为0.482，（U = 3694，P = 0.0011，95%可信区间 = 0.37，0.85）。