银杏叶提取物EGb 761与多奈哌齐治疗高龄阿尔茨海默病痴呆的疗效相似：一项回顾性观察研究。
Similar treatment outcomes with Ginkgo biloba extract EGb 761 and donepezil in Alzheimer's dementia in very old age: A retrospective observational study.
作者信息
Rapp Michael, Burkart Martin, Kohlmann Thomas, Bohlken Jens
出版信息
Int J Clin Pharmacol Ther. 2018 Mar;56(3):130-133. doi: 10.5414/CP203103.
OBJECTIVE
To provide pilot data for the safety and efficacy of EGb 761 in the oldest-old patients (aged 80 or older).
MATERIALS AND METHODS
In a retrospective analysis, we compared treatment outcomes with EGb 761 or donepezil over 12 months in 189 patients aged 80 years or older suffering from Alzheimer's disease (AD).
RESULTS
Over 12 months, there was no significant difference in cognitive decline, measured with the mini-mental state examination (MMSE) score, between donepezil and EGb 761 (p = 0.31). We found more adverse events in the donepezil group.
CONCLUSION: Results suggest similar effects on cognitive symptoms from the use of EGb 761 in the treatment of dementia in AD together with favorable safety compared to donepezil. .
目的
为银杏叶提取物761（EGb 761）在高龄患者（80岁及以上）中的安全性和有效性提供初步数据。
材料与方法
在一项回顾性分析中，我们比较了189例80岁及以上阿尔茨海默病（AD）患者使用EGb 761或多奈哌齐治疗12个月后的治疗效果。
结果
在12个月期间，使用简易精神状态检查表（MMSE）评分衡量，多奈哌齐组和EGb 761组的认知衰退无显著差异（p = 0.31）。我们发现多奈哌齐组的不良事件更多。
结论
结果表明，与多奈哌齐相比，EGb 761用于治疗AD痴呆对认知症状有相似疗效，且安全性良好。
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