Inaba K, Steinman R M
Adv Exp Med Biol. 1985;186:369-76. doi: 10.1007/978-1-4613-2463-8_44.
Dendritic cells (DC) are important accessory cells for T-dependent antibody formation. Other leukocytes -- such as macrophages and B cells -- do not independently initiate antibody responses. DC induce the two principal functions of helper T cells, i.e., direct activation of small, antigen-specific B cells, and release of B cell stimulating factors. These two helper functions can operate in tandem during the 1 degree response to hapten-carrier conjugates. Once the helper cell is sensitized in concert with DC, it interacts directly with B cells apparently in the absence of DC. These functions of helper cells all occur in discrete aggregates which contain DC and the appropriate responding lymphocytes. The DC/lymphocyte aggregates likely represent the appropriate structural unit for the study of cell-cell interactions during antibody responses.
树突状细胞（DC）是T细胞依赖性抗体形成的重要辅助细胞。其他白细胞，如巨噬细胞和B细胞，不会独立引发抗体反应。DC诱导辅助性T细胞的两种主要功能，即直接激活小的、抗原特异性B细胞，以及释放B细胞刺激因子。在对半抗原-载体缀合物的初次反应期间，这两种辅助功能可以协同发挥作用。一旦辅助性细胞与DC协同致敏，它显然可以在没有DC的情况下直接与B细胞相互作用。辅助性细胞的这些功能都发生在含有DC和适当反应性淋巴细胞的离散聚集体中。DC/淋巴细胞聚集体可能代表了研究抗体反应期间细胞间相互作用的合适结构单位。
