Moshetova L K, Sychev D A, Osmanova E R, Turkina K I
Russian Medical Academy of Postgraduate Education, Ministry of Health of the Russian Federation, 2/1 Barrikadnaya St., Moscow, Russian Federation, 123995.
Vestn Oftalmol. 2017;133(6):120-125. doi: 10.17116/oftalma20171336120-125.
The review presents data of clinical and pharmacogenetic research by Russian and foreign authors conducted within the last three years on the effectiveness of anti-angiogenic treatment against wet age-related macular degeneration (AMD). Scientific results on the association between angiogenesis-related gene polymorphisms responsible for predisposition to AMD on the one hand and a positive response to anti-VEGF therapy on the other are presented. Particular attention is paid to the main regulator of angiogenesis - the VEGF-A gene.
这篇综述展示了俄罗斯和外国作者在过去三年里进行的关于抗血管生成治疗湿性年龄相关性黄斑变性（AMD）有效性的临床和药物遗传学研究数据。文中介绍了一方面与AMD易感性相关的血管生成相关基因多态性，另一方面与抗VEGF治疗阳性反应之间关联的科学成果。特别关注了血管生成的主要调节因子——VEGF-A基因。
