在兔子身上进行由聚酯织物增强的硅酮制成的动脉替代物的实验性植入。
Experimental implantation of an arterial substitute made of silicone reinforced with polyester fabric in rabbits.
作者信息
Ribas Laila Massad, Torres Inez Ohashi, Appolonio Fernanda, Rosa Karina Paula Domingos, Espírito-Santo Fabio Rodrigues Ferreira do, Luccia Nelson De
机构信息
Departamento de Cirurgia, Faculdade de Medicina FMUSP, Universidade de Sao Paulo, Sao Paulo, SP, BR.
出版信息
Clinics (Sao Paulo). 2017 Dec;72(12):780-784. doi: 10.6061/clinics/2017(12)10.
OBJECTIVES
The aim of this study was to analyze silicone tubes with an internal diameter of 4 mm as a possible material for vascular prostheses.
METHODS
Grafts were implanted into the infrarenal aortas of 33 rabbits. Fluoroscopic examinations were performed within 150 days after surgical implantation. Sample grafts were analyzed via electron microscopy to evaluate the eventual endothelialization of the prostheses.
RESULTS
The patency rates of the prostheses were 87% (±6.7%) after 30 days, 73% (±9.3%) after 60 days and 48% (±12%) after 120 days. The material presented characteristics that support surgical implantation: good tolerance promoted by polyester tear reinforcement, ease of postoperative removal and a lack of pseudoaneurysms. However, intimal hyperplasia was a limiting factor for the patency rate.
CONCLUSIONS
We concluded that polydimethylsiloxane has limited potential as an alternative material for small vascular prostheses.
目的
本研究旨在分析内径为4毫米的硅胶管作为血管假体可能材料的情况。
方法
将移植物植入33只兔子的肾下腹主动脉。在手术植入后150天内进行荧光透视检查。通过电子显微镜分析样本移植物，以评估假体最终的内皮化情况。
结果
假体的通畅率在30天后为87%（±6.7%），60天后为73%（±9.3%），120天后为48%（±12%）。该材料具有支持手术植入的特性：聚酯撕裂增强促进了良好的耐受性，术后易于移除且无假性动脉瘤。然而，内膜增生是通畅率的一个限制因素。
结论
我们得出结论，聚二甲基硅氧烷作为小血管假体的替代材料潜力有限。
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