Molinaro Francesco, Tyc Olaf, Beekwilder Jules, Cankar Katarina, Bertea Cinzia Margherita, Negre Michèle, Garbeva Paolina
DISAFA, Dipartimento di Scienze Agrarie, Forestali e Agroalimentari, Università degli Studi di Torino, Largo Paolo Braccini 2, 10095 Grugliasco (TO), Italy.
Netherlands Institute of Ecology (NIOO-KNAW), Department of Microbial Ecology, PO BOX 50, 6700 AB Wageningen, The Netherlands.
FEMS Microbiol Lett. 2018 Feb 1;365(4). doi: 10.1093/femsle/fny001.
Ambrosia artemisiifolia L. (common ragweed) is an invasive weed, which is well known for the strong allergenic effect of its pollen as well as for its invasiveness and impact in crop fields (e.g. causing yield losses). This species produces a broad range of sesquiterpenoids. In recent years, new bioactive molecules have been discovered in this plant, e.g. isabelin, a sesquiterpene dilactone. The bioactivity of isabelin has been already demonstrated on allergy-related receptors and its inhibitory effect on seeds of various plant species. Isabelin was tested for potential antimicrobial effects by using a selection of soil-borne bacteria and fungi and three human pathogens as model organisms. For the majority of microorganisms tested, no antimicrobial activity of isabelin was observed. However, isabelin revealed strong antimicrobial activity against the Gram-positive soil bacterium Paenibacillus sp. and against the Gram-positive, multidrug-resistant Staphylococcus aureus. The observed inhibitory activity of isabelin can enlighten the importance to study similar compounds for their effect on human pathogens and on soil and rhizosphere microorganisms.
豚草是一种入侵性杂草，因其花粉具有强烈的致敏作用以及在农田中的入侵性和影响（如导致产量损失）而广为人知。该物种产生多种倍半萜类化合物。近年来，在这种植物中发现了新的生物活性分子，例如倍半萜双内酯伊莎贝林。伊莎贝林的生物活性已在与过敏相关的受体上得到证实，并且对多种植物物种的种子具有抑制作用。通过选择一些土壤传播的细菌和真菌以及三种人类病原体作为模式生物，对伊莎贝林的潜在抗菌作用进行了测试。对于大多数测试的微生物，未观察到伊莎贝林的抗菌活性。然而，伊莎贝林对革兰氏阳性土壤细菌芽孢杆菌属以及革兰氏阳性、多重耐药金黄色葡萄球菌显示出强大的抗菌活性。观察到的伊莎贝林的抑制活性可以说明研究类似化合物对人类病原体以及土壤和根际微生物的影响的重要性。
