Kovács Balázs, Hohmann Judit, Csupor-Löffler Boglárka, Kiss Tivadar, Csupor Dezső
Department of Pharmacognosy, Faculty of Pharmacy, University of Szeged, Eötvös u. 6, H-6720 Szeged, Hungary.
Institute for Translational Medicine, Szentágothai Research Centre, Medical School, University of Pécs, H-7624 Pécs, Hungary.
Heliyon. 2022 Jul 9;8(7):e09884. doi: 10.1016/j.heliyon.2022.e09884. eCollection 2022 Jul.
Sesquiterpenes are bitter secondary metabolites characteristic to the genus (Asteraceae) and constitute one of the most diverse classes of terpenoids. These compounds exhibit broad-spectrum bioactivities, such as antiproliferative, cytotoxic, antimicrobial, anti-inflammatory, molluscicidal, schistomicidal, larvicidal, and antiprotozoal activities. This review compiles and discusses the chemistry and pharmacology of sesquiterpenes of the species covering the period between 1950 and 2021. The review identified 158 sesquiterpenes previously isolated from 23 different species collected from across the American, African, and Asian continents. These compounds have guaiane, pseudoguaiane, seco-pseudoguaiane, daucane, germacrane, eudesmane, oplopane, clavane, and aromadendrane carbon skeletons. Most sesquiterpene compounds predominantly harbor the pseudoguaiane skeleton, whereas the eudesmanes have the most varied substituents. Antiproliferative and antiprotozoal activities are the most promising bioactivities of sesquiterpenes in and could lead to new pathways toward drug discovery.
倍半萜是菊科植物特有的苦味次生代谢产物，是萜类化合物中最多样化的类别之一。这些化合物具有广泛的生物活性，如抗增殖、细胞毒性、抗菌、抗炎、杀螺、杀血吸虫、杀幼虫和抗原虫活性。本综述汇编并讨论了1950年至2021年间菊科植物倍半萜的化学和药理学。该综述鉴定了先前从美洲、非洲和亚洲大陆收集的23种不同菊科植物中分离出的158种倍半萜。这些化合物具有愈创木烷、伪愈创木烷、裂环伪愈创木烷、胡萝卜烷、吉马烷、桉叶烷、奥洛烷、克拉烷和芳樟烷碳骨架。大多数倍半萜化合物主要具有伪愈创木烷骨架，而桉叶烷类具有最多样化的取代基。抗增殖和抗原虫活性是菊科植物倍半萜最有前景的生物活性，可能会为药物发现带来新途径。
