Fraunfelder F T, LaBraico J M, Meyer S M
Am J Ophthalmol. 1985 Oct 15;100(4):534-7. doi: 10.1016/0002-9394(85)90676-2.
A total of 261 adverse ocular reactions occurred in 237 patients who received isotretinoin, a commonly used drug in the treatment of severe cystic acne. Blepharoconjunctivitis, subjective complaints of dry eyes, blurred vision, contact lens intolerance, and photodermatitis are reversible side effects. More serious ocular adverse reactions include papilledema, pseudotumor cerebri, and white or gray subepithelial corneal opacities; all of these are reversible if the drug is discontinued. Reported cases of decreased dark adaptation are under investigation. Isotretinoin is contraindicated in pregnancy because of the many reported congenital abnormalities after maternal use (including microphthalmos, orbital hypertelorism, and optic nerve hypoplasia).
在237名接受异维甲酸治疗的患者中，共发生了261例眼部不良反应，异维甲酸是治疗重度囊肿性痤疮的常用药物。睑结膜炎、干眼主观症状、视力模糊、隐形眼镜不耐受和光性皮炎是可逆的副作用。更严重的眼部不良反应包括视乳头水肿、假性脑瘤和白色或灰色角膜上皮下混浊；如果停药，所有这些都是可逆的。报道的暗适应下降病例正在调查中。由于有许多关于母亲使用异维甲酸后出现先天性异常的报道（包括小眼症、眼眶增宽和视神经发育不全），异维甲酸在孕期禁用。
