三氟甲基乙烯基砜：含 CFS 的异噁唑烷合成的砌块。
Trifluoromethyl Vinyl Sulfide: A Building Block for the Synthesis of CFS-Containing Isoxazolidines.
机构信息
Radboud University , Institute for Molecules and Materials, Heyendaalseweg 135, 6525 AJ Nijmegen, The Netherlands.
Department of Theoretical Chemistry and Amsterdam Center for Multiscale Modeling (ACMM), Vrije Universiteit Amsterdam , De Boelelaan 1083, 1081 HV Amsterdam, The Netherlands.
出版信息
J Org Chem. 2018 Feb 16;83(4):1779-1789. doi: 10.1021/acs.joc.7b02639. Epub 2018 Jan 30.
Abstract
Trifluoromethyl vinyl sulfide, a potential building block for pharmaceutically and agrochemically relevant products, is prepared and used for the first time in high-pressure-mediated 1,3-dipolar cycloaddition reactions with nitrones to synthesize (trifluoromethyl)sulfanyl isoxazolidines.
摘要
三氟甲基乙烯基砜，一种潜在的医药和农用化学品相关产品的构建模块，首次被用于与硝酮的高压介导的 1,3-偶极环加成反应中，以合成（三氟甲基）硫代异噁唑烷。
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