Venturoli S, Paradisi R, Saviotti E, Porcu E, Fabbri R, Orsini L F, Bovicelli L, Flamigni C
Arch Gynecol. 1985;237(1):1-10. doi: 10.1007/BF02133945.
Women with the polycystic ovary syndrome were treated cyclically for two years with an oral oestrogen/progestogen combination of 50 mg of cyproterone acetate and 0.05 mg of ethinyloestradiol. Ovarian volume, ovarian texture and uterine size were monitored by ultrasound before, during and after treatment. Menstrual rhythm, ovulation and the degree of hirsutism were also studied clinically. A significant decrease in the ovarian volume and in the number of cystic areas was observed during treatment. Hirsutism was also markedly improved. Some of these beneficial effects persisted after treatment was stopped. The number of subjects who had regular, ovulatory cycles increased after stopping treatment. Growth of uterine muscle occurred during treatment.
患有多囊卵巢综合征的女性接受了为期两年的周期性治疗，采用口服雌激素/孕激素联合制剂，其中醋酸环丙孕酮50毫克，炔雌醇0.05毫克。在治疗前、治疗期间和治疗后，通过超声监测卵巢体积、卵巢质地和子宫大小。还对月经节律、排卵和多毛程度进行了临床研究。治疗期间观察到卵巢体积和囊性区域数量显著减少。多毛症也有明显改善。治疗停止后，其中一些有益效果仍然存在。停止治疗后，有规律排卵周期的受试者数量增加。治疗期间子宫肌层出现生长。
