通过靶向 CD38 NADase 进行代谢重编程增强过继性 T 细胞疗法。
Metabolic Reprogramming via Targeting CD38 NADase Augments Adoptive T Cell Therapy.
机构信息
Department of Tumor Biology, H. Lee Moffitt Cancer Center and Research Institute, Tampa, FL 33612, USA.
Department of Tumor Biology, H. Lee Moffitt Cancer Center and Research Institute, Tampa, FL 33612, USA.
出版信息
Cell Metab. 2018 Jan 9;27(1):3-5. doi: 10.1016/j.cmet.2017.12.014.
PMID:29320709
Abstract
One strategy to improve the potency of adoptive T cell therapy is to augment the function and persistence of anti-tumor T cells. In this issue of Cell Metabolism, Chatterjee et al. (2018) demonstrate that intratumoral CD4 T cell functions and memory can be improved by targeting a CD38-NAD-Sirt1-Foxo1 metabolic circuit.
摘要
提高过继性 T 细胞疗法疗效的一种策略是增强抗肿瘤 T 细胞的功能和持久性。在本期《细胞代谢》中，Chatterjee 等人（2018 年）证明，通过靶向 CD38-NAD-Sirt1-Foxo1 代谢通路可以改善肿瘤内 CD4 T 细胞的功能和记忆。
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