Signal Transduction and Molecular Nutrition Laboratory, Kogod Aging Center, Department of Anesthesiology and Perioperative Medicine, Mayo Clinic College of Medicine, Rochester, Minnesota, USA.
Department of Anesthesiology and Perioperative Medicine, Mayo Clinic, Jacksonville, Florida, USA.
Aging Cell. 2022 Apr;21(4):e13589. doi: 10.1111/acel.13589. Epub 2022 Mar 8.
Nicotinamide adenine dinucleotide (NAD) levels decline during aging, contributing to physical and metabolic dysfunction. The NADase CD38 plays a key role in age-related NAD decline. Whether the inhibition of CD38 increases lifespan is not known. Here, we show that the CD38 inhibitor 78c increases lifespan and healthspan of naturally aged mice. In addition to a 10% increase in median survival, 78c improved exercise performance, endurance, and metabolic function in mice. The effects of 78c were different between sexes. Our study is the first to investigate the effect of CD38 inhibition in naturally aged animals.
烟酰胺腺嘌呤二核苷酸 (NAD) 水平随年龄增长而下降，导致身体和代谢功能障碍。NAD 水解酶 CD38 在与年龄相关的 NAD 下降中起关键作用。抑制 CD38 是否能延长寿命尚不清楚。本文研究显示，CD38 抑制剂 78c 可延长自然衰老小鼠的寿命和健康寿命。除了中位生存期延长 10%外，78c 还改善了小鼠的运动表现、耐力和代谢功能。78c 的作用在性别之间存在差异。本研究首次在自然衰老动物中研究了 CD38 抑制的效果。
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