Department of Pathology, The People's Hospital of Liaocheng, Liaocheng, P.R. China; Department of Surgery, Qilu Hospital, Shandong University, Jinan, P.R. China.
Department of Pathology, QiLu Hospital, Shandong University, Jinan, P.R. China.
Hum Pathol. 2018 Apr;74:156-163. doi: 10.1016/j.humpath.2018.01.004. Epub 2018 Jan 7.
Chemotherapy plays an important role in the treatment of breast cancer. However, chemoresistance remains the main obstacle for effective treatment, leading to poor prognosis. This study aims to investigate the value of detection of S100A8 and ASAH1 in predicting the chemotherapy response. Miller and Payne grades were used to assess the chemotherapy response in breast cancers. The expression of S100A8 and ASAH1, as well as ER, PR, HER2 and Ki-67 were assessed by immunohistochemical staining in 120 cases of non-special type invasive ductal carcinoma (IDC-NOS). S100A8 expression was higher in chemosensitive breast cancers than chemoresistant ones. Moreover, S100A8 expression was significantly correlated with the molecular subtypes and histological grade, but not with patients' age, tumor size and lymph nodes status. However, there was no significant difference in ASAH1 expression between chemoresistant and chemosensitive group. We also found that higher ASAH1 expression was correlated with positive lymph nodes status, but not with age, tumor size, molecular subtypes and histological grade. S100A8 was valuable in predicting chemotherapy response in breast cancers. The expression of ASAH1 was associated significantly with lymph nodes metastasis, indicating that ASAH1 may serve as a biomarker to predict patients' lymph nodes status in breast cancers.
化疗在乳腺癌治疗中起着重要作用。然而，化疗耐药仍然是有效治疗的主要障碍，导致预后不良。本研究旨在探讨检测 S100A8 和 ASAH1 对预测化疗反应的价值。采用 Miller 和 Payne 分级评估乳腺癌的化疗反应。对 120 例非特殊型浸润性导管癌（IDC-NOS）进行免疫组化染色，检测 S100A8 和 ASAH1 的表达以及 ER、PR、HER2 和 Ki-67。在敏感组中，S100A8 的表达高于耐药组。此外，S100A8 的表达与分子亚型和组织学分级显著相关，但与患者年龄、肿瘤大小和淋巴结状态无关。然而，在耐药组和敏感组之间，ASAH1 的表达没有显著差异。我们还发现，较高的 ASAH1 表达与阳性淋巴结状态相关，但与年龄、肿瘤大小、分子亚型和组织学分级无关。S100A8 对预测乳腺癌的化疗反应有价值。ASAH1 的表达与淋巴结转移显著相关，表明 ASAH1 可作为预测乳腺癌患者淋巴结状态的生物标志物。
