Hockley B, Johnson N M
Br J Dis Chest. 1985 Oct;79(4):379-84. doi: 10.1016/0007-0971(85)90072-5.
We have performed a double-blind crossover study in nine patients with stable chronic asthma, in order to evaluate the effects of three doses of the anticholinergic bronchodilator ipratropium bromide (80 micrograms, 200 micrograms and 400 micrograms) given by metered dose inhaler. These doses are larger than the recommended dose (40 micrograms). All three doses of the drug produced significant bronchodilation from 15 minutes to 5 hours. Some small but statistically significant differences were found in favour of the 200 micrograms and 400 micrograms doses when compared with the 80 micrograms dose and the duration of action of the 400 micrograms dose was longer than that of 200 micrograms dose. The clinical usefulness of these small differences remains to be assessed.
我们对9例稳定期慢性哮喘患者进行了一项双盲交叉研究，以评估通过定量吸入器给予三剂抗胆碱能支气管扩张剂异丙托溴铵（80微克、200微克和400微克）的效果。这些剂量大于推荐剂量（40微克）。所有三剂药物在15分钟至5小时内均产生了显著的支气管扩张作用。与80微克剂量相比，发现200微克和400微克剂量存在一些虽小但具有统计学意义的差异，且400微克剂量的作用持续时间长于200微克剂量。这些微小差异的临床实用性仍有待评估。
