Yılmaz Tonguç Utku, Trabzonlu Levent, Güler Sertaç Ata, Baran Mehmet Ali, Pösteki Gökhan, Erçin Cengiz, Utkan Zafer
Department of General Surgery, Kocaeli University School of Medicine, Kocaeli, Turkey.
Department of Pathology, Kocaeli University School of Medicine, Kocaeli, Turkey.
Eur J Breast Health. 2018 Jan 1;14(1):17-22. doi: 10.5152/ejbh.2017.3219. eCollection 2018 Jan.
Breast cancer is a heterogeneous disease with different histological types. Ductal breast cancer constitutes the vast majority of the breast cancers. However limited data are present in the rest of breast cancers called special or rare type breast cancers. Here in this study, we tried to describe the clinical features of special type breast cancers in our center.
Retrospective descriptive study was performed in Kocaeli University School of Medicine, Department of General Surgery between January 2000 and January 2016. Women diagnosed with primary breast cancer other than ductal carcinoma were included to the study. In total, 101 patients were evaluated according to histologic types, molecular types, Tumor Node Metastasis (TNM) stages, and grades. Survival of the patients was also evaluated.
Medullary and metaplastic types showed basal type; tubular, mucinous, micropapillary carcinoma, cribriform, lobular and apocrine tumors showed luminal type molecular pattern. Neither the existence of ductal carcinoma nor any histologic types had any effects on survival. Apocrine tumors were presented in younger ages.
Histologic types of breast cancer are closely related with the molecular types of the breast cancer. Tumor size, grade, stage of the disease can show differences among histological types which might be due to the genetic background, late onset or limited number of patients. In order to achieve more significant results, multicenter national studies are needed.
乳腺癌是一种具有不同组织学类型的异质性疾病。乳腺导管癌占乳腺癌的绝大多数。然而，在其余被称为特殊或罕见类型乳腺癌的病例中，相关数据有限。在本研究中，我们试图描述我院特殊类型乳腺癌的临床特征。
于2000年1月至2016年1月在科贾埃利大学医学院普通外科进行回顾性描述性研究。纳入诊断为非导管癌的原发性乳腺癌女性患者。总共101例患者根据组织学类型、分子类型、肿瘤淋巴结转移（TNM）分期和分级进行评估。还对患者的生存率进行了评估。
髓样和化生型表现为基底型；管状、黏液性、微乳头状癌、筛状、小叶和大汗腺癌表现为管腔型分子模式。导管癌的存在与否及任何组织学类型均对生存率无影响。大汗腺癌患者发病年龄较轻。
乳腺癌的组织学类型与分子类型密切相关。肿瘤大小、分级、疾病分期在不同组织学类型之间可能存在差异，这可能归因于遗传背景、发病较晚或患者数量有限。为了获得更显著的结果，需要开展多中心全国性研究。
