Kirejczyk Shannon G, Burnum Anne L, Brown Corrie C, Sakamoto Kaori, Rissi Daniel R
Department of Pathology (Kirejczyk, Burnum, Brown, Sakamoto, Rissi), College of Veterinary Medicine, University of Georgia, Athens, GA.
Athens Veterinary Diagnostic Laboratory (Rissi), College of Veterinary Medicine, University of Georgia, Athens, GA.
J Vet Diagn Invest. 2018 May;30(3):479-482. doi: 10.1177/1040638717753964. Epub 2018 Jan 11.
Mesothelial papillary hyperplasia (MPH) has been described as an incidental finding on the epicardial surface of clinically normal laboratory Beagle dogs. We describe MPH in 4 dogs diagnosed with acute cardiac tamponade (1 case) or chronic cardiac disease (3 cases). Cardiac MPH appeared as distinct, soft, irregular villous plaques on the epicardial surface of the auricles and occasionally the ventricles. Histologically, areas of MPH were composed of multiple papillary fronds arising from the epicardial surface and projecting into the pericardial space. Fronds were covered by cuboidal and occasionally vacuolated mesothelial cells and were supported by loose fibrovascular stroma with various degrees of edema and inflammation. Although these may represent incidental findings with no clinical significance, the gross appearance warrants differentiation from other conditions. Additional insight into the pathogenesis of MPH is needed to fully understand its significance in the face of concurrent cardiac disease.
间皮乳头状增生（MPH）已被描述为临床正常的实验比格犬心外膜表面的偶然发现。我们描述了4只被诊断为急性心脏压塞（1例）或慢性心脏病（3例）的犬的MPH情况。心脏MPH表现为心耳表面以及偶尔心室表面明显的、柔软的、不规则的绒毛状斑块。组织学上，MPH区域由从心外膜表面长出并突入心包腔的多个乳头状叶组成。叶被立方体细胞覆盖，偶尔还有空泡化的间皮细胞，并由伴有不同程度水肿和炎症的疏松纤维血管间质支撑。尽管这些可能是无临床意义的偶然发现，但大体外观仍需与其他情况相鉴别。需要对MPH的发病机制有更多了解，以便在并发心脏病的情况下充分理解其意义。
