氨曲南在单纯性淋病治疗中的应用。

The use of aztreonam in the treatment of uncomplicated gonorrhoea.

作者信息

Spencer R C, Talbot M D

出版信息

Curr Med Res Opin. 1985;9(9):591-3. doi: 10.1185/03007998509109639.

Abstract

A total of 57 men and 26 women with uncomplicated gonorrhoea was treated with 1 g aztreonam intramuscularly. The cure rate was 96% and included successful treatment of 4 infections due to beta-lactamase producing organisms and 8 patients with pharyngeal involvement. The minimum inhibitory concentrations of aztreonam in vitro were lower than those of penicillin and similar to cefuroxime, and side-effects were minimal. It is concluded that aztreonam is effective against Neisseria gonorrhoeae in vivo and in vitro.

摘要

总共57名男性和26名女性单纯性淋病患者接受了1克氨曲南肌肉注射治疗。治愈率为96%，其中包括成功治疗了4例由产β-内酰胺酶的微生物引起的感染以及8例有咽部感染的患者。氨曲南的体外最低抑菌浓度低于青霉素，与头孢呋辛相似，且副作用极小。结论是氨曲南在体内和体外对淋病奈瑟菌均有效。