Perez C, Herson J, Kimball J C, Sutow W W
Cancer Clin Trials. 1978 Winter;1(4):315-20.
Data from 106 patients with osteosarcoma who developed metastases during treatment were analyzed for prognostic factors for postmetastic survival time. Patients diagnosed in 1971 or later received more intensive chemotherapy and had significantly longer postmetastatic survival time than those diagnosed in 1970 or earlier (P = 0.002). Patients whose metastasis occurred 13 or more months after diagnosis had signicantly longer postmetastatic survival time than those whose metastasis occurred during the first 12 months after diagnosis (P = 0.005). Life-table regression analysis revealed an interaction between "year of diagnosis" and "months to metastasis" which provided a postmetastatic survival advantage for those having metastasis after diagnosis over metastasis at diagnosis for patients diagnosed in 1971 or later but not for those diagnosed in 1970 or earlier (P = 0.093).
对106例在治疗期间发生转移的骨肉瘤患者的数据进行分析，以寻找转移后生存时间的预后因素。1971年或之后确诊的患者接受了更强化的化疗，其转移后的生存时间显著长于1970年或之前确诊的患者（P = 0.002）。转移发生在诊断后13个月或更长时间的患者，其转移后的生存时间显著长于转移发生在诊断后前12个月内的患者（P = 0.005）。寿命表回归分析显示，“诊断年份”和“转移发生时间（月）”之间存在交互作用，对于1971年或之后确诊的患者，诊断后发生转移的患者较诊断时即发生转移的患者有转移后生存优势，但对于1970年或之前确诊的患者则无此优势（P = 0.093）。
