Sutow W W, Herson J, Perez C
Natl Cancer Inst Monogr. 1981 Apr(56):227-31.
We analyzed survival patterns of 106 patients with metastatic osteosarcoma treated at the M. D. Anderson Hospital from 1954 to 1975. All were 20 years of age or less, had a confirmed diagnosis of medullary osteosarcoma (excluding mandibular and radiogenic osteosarcoma), and had developed evidence of metastasis at diagnosis or during treatment. Clinical characteristics evaluated statistically as possible prognostic factors in postmetastatic survival were: age at diagnosis, sex, race, site or primary, site of first metastasis, year of diagnosis, and time from diagnosis to metastasis. Two factors, year of diagnosis and time to metastasis, showed statistically significant association with postmetastastic survival. Those patients treated in 1971 or later (62) had significantly longer postmetastatic survival times than those (44) treated in 1970 or earlier (P = 0.002). Also, 14 patients who developed metastasis 1 year or more after diagnosis had significantly longer postmetastatic survival times than the 19 with metastasis at diagnosis (P = 0.002) or the 73 who developed metastasis during the 1st year after diagnosis (P = 0.005). Analysis also indicated a statistically significant interaction effect between the two factors (P = 0.093) that suggested the time to metastasis had a greater influence on postmetastatic survival time in those diagnosed in 1971 or later than in those diagnosed earlier.
我们分析了1954年至1975年在MD安德森医院接受治疗的106例转移性骨肉瘤患者的生存模式。所有患者年龄均在20岁及以下，确诊为髓性骨肉瘤（不包括下颌骨和放射性骨肉瘤），且在诊断时或治疗期间已出现转移证据。作为转移后生存可能的预后因素进行统计学评估的临床特征包括：诊断时年龄、性别、种族、原发部位、首次转移部位、诊断年份以及从诊断到转移的时间。两个因素，即诊断年份和转移时间，与转移后生存显示出统计学上的显著关联。1971年或之后接受治疗的患者（62例）转移后的生存时间明显长于1970年或之前接受治疗的患者（44例）（P = 0.002）。此外，诊断后1年或更长时间出现转移的14例患者转移后的生存时间明显长于诊断时即出现转移的19例患者（P = 0.002）或诊断后第1年出现转移的73例患者（P = 0.005）。分析还表明这两个因素之间存在统计学上的显著交互作用（P = 0.093），这表明转移时间对1971年或之后诊断的患者转移后生存时间的影响大于对早期诊断患者的影响。
