通过烯胺氧化催化不对称脱氢反应制备 4-取代环己酮。
Catalytic Desymmetrizing Dehydrogenation of 4-Substituted Cyclohexanones through Enamine Oxidation.
机构信息
Key Laboratory of Molecular Recognition and Function, Institute of Chemistry, Chinese Academy of Sciences, Beijing, 100190, China.
University of Chinese Academy of Sciences, Beijing, 100490, China.
出版信息
Angew Chem Int Ed Engl. 2018 Feb 19;57(8):2253-2258. doi: 10.1002/anie.201713327. Epub 2018 Feb 2.
PMID:29323448
Abstract
A desymmetrizing dehydrogenation process catalyzed by a chiral primary amine is described herein. The reaction proceeds through the oxidation of a ketone enamine by IBX and enables the highly enantioselective desymmetrization of 4-substituted cyclohexanones with the generation of chiral 4-substituted cyclohexenones containing a remote γ-stereocenter.
摘要
本文描述了一种由手性伯胺催化的去对称脱氢过程。该反应通过 IBX 对酮烯胺的氧化进行，并能够对 4-取代环己酮进行高度对映选择性的去对称化，生成含有远程 γ-立体中心的手性 4-取代环己烯酮。
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