酮的烯胺氧化催化不对称 β-C-H 官能化。
Catalytic Asymmetric β-C-H Functionalizations of Ketones via Enamine Oxidation.
机构信息
Key Laboratory of Molecular Recognition and Function , Chinese Academy of Sciences , Beijing 100190 , China.
College of Chemistry and Chemical Engineering , University of Chinese Academy of Sciences , Beijing 100490 , China.
出版信息
Org Lett. 2018 Mar 16;20(6):1672-1675. doi: 10.1021/acs.orglett.8b00508. Epub 2018 Mar 7.
PMID:29513019
Abstract
A chiral primary amine catalyzed oxidative β-C-H functionalization of ketone is described. The reaction proceeds via ketone enamine oxidation by IBX and enables highly enantioselective remote C-H functionalization of both cyclic and acyclic ketones, generating chiral ketones bearing β-stereocenters.
摘要
一种手性伯胺催化的酮的氧化 β-C-H 官能化反应被描述。该反应通过 IBX 对酮烯胺的氧化进行，能够对环状和非环状酮进行高度对映选择性的远程 C-H 官能化，生成具有 β-手性中心的手性酮。
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