系统性硬化症和系统性红斑狼疮的微血管受累。
Microvascular involvement in systemic sclerosis and systemic lupus erythematosus.
机构信息
Department of Internal Medicine, University of Pittsburgh Medical Center, Pittsburgh, PA, USA.
Department of Pulmonary, Allergy and Critical Care Medicine, Respiratory Institute, Cleveland Clinic, Cleveland, OH, USA.
出版信息
Microcirculation. 2019 Apr;26(3):e12440. doi: 10.1111/micc.12440.
Abstract
Microvascular changes play central roles in the pathophysiology of SSc and SLE, and represent major causes of morbidity and mortality in these patients. Therefore, clinical tools that can assess the microvasculature are of great importance both at the time of diagnosis and follow-up of these cases. These tools include capillaroscopy, laser imaging techniques, infrared thermography, and iontophoresis. In this review, we examined the clinical manifestations and pathobiology of microvascular involvement in SSc and SLE as well as the methodologies used to evaluate the microvasculature.
摘要
微血管变化在 SSc 和 SLE 的病理生理学中起着核心作用，是这些患者发病率和死亡率的主要原因。因此，在这些病例的诊断和随访时，能够评估微血管的临床工具具有重要意义。这些工具包括毛细血管镜检查、激光成像技术、红外热成像和离子电渗疗法。在这篇综述中，我们检查了 SSc 和 SLE 中小血管受累的临床表现和病理生物学，以及用于评估微血管的方法学。
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